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RWJ 63556
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RWJ 63556图片
CAS NO:190967-35-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
RWJ63556是一种可口服的COX-2selective/5-lipoxygenase抑制剂，具有抗炎活性。
Cas No.190967-35-2
Canonical SMILESCS(=O)(NC1=CC=C(OC2=CC=C(F)C=C2)S1)=O
分子式C11H10FNO3S2
分子量287.33
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].

RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].

[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.