HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with anIC₅₀value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy^[1].

HPK1-IN-31(compound 5i) (p.o., 30 或 100 mpk，每天两次，14天) 在 CT26 肿瘤雌性 BALB/c 小鼠模型和 MC38 肿瘤雌性 C57BL/6 小鼠模型中，可以抑制肿瘤的生长，并且与抗 PD-1 单药联用时效果更明显^[1]。

539.63

C₃₀H₃₃N₇O₃

Room temperature in continental US; may vary elsewhere.

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