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2-Oleoyl Glycerol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Oleoyl Glycerol图片
CAS NO:3443-84-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
2-油酰甘油是一种膳食天然存在的脂质。
Cas No.3443-84-3
别名2-十八烯酸单甘油酯；2-甘油单油酸酯
化学名2-hydroxy-1-(hydroxymethyl)ethyl ester-9Z-octadecenoic acid
Canonical SMILESCCCCCCCC/C=C\CCCCCCCC(OC(CO)CO)=O
分子式C21H40O4
分子量356.5
溶解度10 mg/ml in DMSO, 10 mg/ml in DMF, 15 mg/ml in Ethanol
储存条件Store at -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol , is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases.[1][2][3] 2-OG is an agonist of GPR119 (EC50 = 2.5 &#181M), stimulating the release of glucagon-like peptide-1 from intestinal L-cells. [4]

Reference:
[1]. Brengdahl, J., and Fowler, C.J. A novel assay for monoacylglycerol hydrolysis suitable for high-throughput screening. Analytical Biochemistry 359, 40-44 (2006).
[2]. Ghafouri, N., Tiger, G., Razdan, R.K., et al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. British Journal of Pharmacology 143, 774-784 (2004).
[3]. Woodhams, S.G., Wong, A., Barrett, D.A., et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. Brit.J.Pharmacol. 167, 1609-1619 (2012).
[4]. Hansen, K.B., Rosenkilde, M.M., Knop, F.K., et al. 2-Oleoyl glycerol is a GRP119 agonist and signals GLP-1 release in humans. Journal of Clinical Endocrinology and Metabolism 96(9), E1409-E1417 (2011).