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CK 666
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CK 666图片
CAS NO:442633-00-3
包装与价格：
包装价格(元)
50mg电议
10mg电议

产品介绍
CK 666 是一种可渗透细胞的肌动蛋白相关蛋白 Arp2/3 复合物抑制剂 (IC50\u003d12 μM)。
Cas No.442633-00-3
化学名2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
Canonical SMILESFC1=CC=CC=C1C(NCCC2=C(C)NC3=CC=CC=C23)=O
分子式C18H17FN2O
分子量296.34
溶解度<29.63mg/ml in DMSO;<29.63mg/ml in ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].

References:
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.