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ASP2453
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ASP2453图片
CAS NO:2241719-73-1
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
ASP2453是一种强效、选择性和共价的KRAS G12C抑制剂。ASP2453抑制Son of Sevenless (SOS)介导的KRAS G12C和Raf之间的相互作用，IC50值为40 nM。
Cas No.2241719-73-1
分子式C40H48F3N7O4
分子量747.85
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.

[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.