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Tirabrutinib hydrochloride(ONO-4059(hydrochloride))
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tirabrutinib hydrochloride(ONO-4059(hydrochloride))图片
CAS NO:1439901-97-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Tirabrutinib (ONO-4059) hydrochloride 是一种具有口服活性的 Bruton's Tyrosine Kinase (BTK) 抑制剂（可以穿过血脑屏障 (BBB)），IC50 为 6.8 nM。
Cas No.1439901-97-9
别名ONO-4059 hydrochloride; GS-4059 hydrochloride
Canonical SMILESO=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl
分子式C25H23ClN6O3
分子量490.94
溶解度DMSO: 17.86 mg/mL (36.38 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

[1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. [2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.