An internal standard for the quantification of 6-MMP
货号:ajcx25926
CAS:33312-93-5
分子式:C6H3D3N4S
分子量：169.2
溶解度:DMF: 15 mg/ml,DMSO: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

6-Methylmercaptopurine-d₃(6-MMP-d₃) is intended for use as an internal standard for the quantification of 6-MMP by GC- or LC-MS. 6-MMP is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine .¹It is formed from 6-MPviamethylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP.²

1.Rieder, M.J., and Carleton, B.Pharmacogenomics and adverse drug reactions in childrenFront. Genet.578(2014) 2.van Egmond, R., Chin, P., Zhang, M., et al.High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatmentAliment. Pharmacol. Ther.35(10)1181-1189(2012)