Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).

669089-53-6

C51H66N10O12S2

1075.26

Urantide

H2O:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years