SCH 39166 hydrobromide (SCH391660) 是一种有效和选择性的多巴胺D1/D5受体拮抗剂，Ki值分别为 1.2 nM 和 2.0 nM。SCH 39166 hydrobromide 对 D2、D4、5-HT 和 α2a 受体 (Ki值分别为0.98，5.52，0.08 和 0.73 μM) 表现出超过 40 倍的选择性。SCH 39166 hydrobromide 可用于精神分裂症、可卡因成瘾和肥胖症的研究。

SCH 39166 hydrobromide (SCH391660) is potent and selective dopamine D1/D5 receptor antagonist with Kis of 1.2 nM and 2.0 nM, respectively. SCH 39166 hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (K i =0.98, 5.52, 0.08, and 0.73 μM, respectively). SCH 39166 hydrobromide can be used for the research of schizophrenia, cocaine addition, and obesity [1].

The proconvulsive effect of 10 μM dopamine in isolated corticohippocampal formation was completely abolished by the D1-like receptor antagonist SCH39166 (2 μM) hydrobromide [2].

SCH 39166 (0.003-0.3 mg/kg; a single s.c.) hydrobromide abolishes the reinforcement-enhancing effect (REE) of nicotine in adult rats[3]. Animal Model: Male young adult Long-Evans rats were injected with Nicotine [3] Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg) Result: Dose-dependently reduced pressing on both active and inactive levers.

1227675-51-5

C19H21BrClNO

394.73

SCH 39166 hydrobromide

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years