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TP-TRFS
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TP-TRFS图片
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
TP-TRFS是高度选择性的、首个硫氧还蛋白还原酶(TrxR)双光子荧光探针。
Canonical SMILESCC(C1=CC=C2C=C(C=CC2=C1)NC(OC3CSSC3)=O)=O
分子式C16H15NO3S2
分子量333.43
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR)[1].

TP-TRFS (10 μM) exhibits weak fluorescence (φ = 0.57%, absolute quantum yield), and after TP-TRFS (10 μM)) is incubated with TCEP (1 mM), a dramatic fluorescence increment at 490 nm is observed (φ= 22.31%, absolute quantum yield) and the fluorescence intensity of the test system increased by B40-fold within 3 h[1].

TP-TRFS has the ability to visualize the TrxR activity in vivo, and also provides a mechanistic link between stroke and the loss of TrxR function, which may open up a new therapeutic window of stroke via the regulation of TrxR function[1].

[1]. Jintao Zhao, et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chem Commun (Camb). 2020 Nov 12;56(90):14075-14078.