Z164597606

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Z164597606

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1050587-57-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Z164597606 是一种选择性的BChE抑制剂 (IC₅₀:eqBChE 和 hBChE 分别为 1.3 和 1.7 μM)。Z164597606 与 hBChE 的 Trp82 氨基酸形成 π-π 堆积相互作用。Z164597606 可用于阿尔茨海默病 (AD) 的研究。

生物活性

Z164597606 is a selectiveBChEinhibitor (IC₅₀: 1.3 and 1.7 μM foreqBChEand hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)^[1]^[2].

IC₅₀& Target^[1]

eqBCHE

1.3 μM (IC₅₀)

hBCHE

1.7 μM (IC₅₀)

体外研究
(In Vitro)

Z164597606 (10 μM) potently inhibits BChE activity, with no more than 30% inhibitory against ACHE^[1].
Z164597606 (0.5-20 μM) may bind to catalytic “anionic” site (CAS) when interacting with BChE (determined by Lineweaver-Burk reciprocal plots)^[1].
Z164597606 (10 and 50 μM) shows no toxicity on neuronal cell line SH-SY5Y^[1].

分子量

365.38

Formula

C₂₀H₁₉N₃O₄

CAS 号

1050587-57-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.