MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with anIC₅₀of 5 nM.

IC50: 5 nM (MARK)^[1]

MARK-IN-2 (Compound 27) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. MARK-IN-2 inhibits MARK3 with an IC₅₀of 5 nM. MARK-IN-2 also inhibits MARK3 in primary cell culture of rat cortical neurons with an IC₅₀of 280 nM^[1].

Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives. MARK-IN-2 (Compound 27) has moderate terminal elimination half-life (t_1/2=0.7 h, and 1 h for rat and dog)^[1].

425.88

C₁₈H₁₈ClF₂N₅OS

1314893-26-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.