Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer ofapoptosisin numerouscancercells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt andNF-κBwhich are generally deregulated in several cancers^[1].

Curcumol ((-)-Curcumol) is the major component extracted from root ofRhizoma Curcumae. Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3^[2]
. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway^[3]
. Curcumol suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways^[4].

236.35

Solid

C₁₅H₂₄O₂

4871-97-0

姜黄醇

• Terpenoids
• Sesquiterpenes

• Plants
• Zingiberaceae
• Curcuma zedoaria

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 100 mg/mL(423.10 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： 10% DMSO    90%corn oil

  Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

  此方案可获得 ≥ 2.5 mg/mL (10.58 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

  以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。