N-(Amino-PEG5)-N-bis(PEG4-acid) is aPEG-basedPROTAClinkerused in the synthesis ofPROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

776.91

Viscous liquid

C₃₄H₆₈N₂O₁₇

2093152-86-2

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)