Technical Notes:

1. Biaryl bisphos phine ligand with narrow dihedral angle. The SEGPHOS® ligand has been applied to a variety of metal catalyzed reactions. In many cases, yields and enantios electivities, exceed results obtained earlier using BINAP

2.As ruthenium complex, SEGPHC S® generally gives higher levels of chiral induction in as ymmetric hydrogenations of a,ß,and y-functionalized ketones. See ruthenium complexes 44-0096, 44-0518, 44-01 68

3.Used in Rh-catalyzed transformations such as: (a) 1,4-addition of boronic acids to coumarins, (b) addition of titanium reagents to imines,' (c) cotrimerization of alkenes and acetylenes,o (d) double 2+2+2 cycloaddition," (e) indanone formation.a,

4.Used in Pd-catalyzed transformations such as: (a) cycloaddition of 1,6-enyne, (b) arylative cyclization of allenyl aldehydes with boronic acids,13 (c) synthesis of chromans.

5.Used in Cu-catalyzed transformations such as: (a) nitroso Diels-Alder,' (b) reductive aldol

6.condensation, (c) conjugate reduction of unsaturated sulfones, and phophonates

7.Iridium-catalyzed asymmetric hydrogenation of quinolines activated by chloroformates

8.Iridium-catalyzed asymmetric transfer hydrog enation used in polyketide construction.

9.Rhodium-catalyzed asymmetric hydroarylation of 3-pyrrolines.

10.P alladium-catalyzed regio- and enantioselective dearomatization of pyrroles to 2H-pyrroles.' Rhodium-catalyzed as ymmetric synthesis of cyclopentanols.0

11. Silver-catalyzed as ymmetric Mannich-type reac tion.