产品描述

CVT-313是有效的CDK2抑制剂，在体外的IC50值为0.5 μM。它对其他非相关的、依赖于ATP的丝氨酸/苏氨酸激酶没有作用。

靶点（IC50 & Targe）

CDK1,4.2μM

CDK2,0.5μM

CDK4,215μM

体外研究

In cells exposed to CVT-313, hyperphosphorylation of the retinoblastoma gene product is inhibited, and progression through the cell cycle is arrested at the G1/S boundary. The growth of mouse, rat, and human cells in culture is also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 μM. CVT-313 inhibits Rb hyperphosphorylation[1].

细胞实验

Cell lines: MRC-5 cells

Concentrations: 12.5 μM

Incubation Time: 24 h

Method: --

(Only for Reference)

动物实验

Animal Models: Rat carotid artery model of restenosis

Formulation: saline

Dosages: 0.025, 0.25, 0.75, 1.25 mg/kg

Administration: intraluminal

(Only for Reference)

参考文献

[1] Brooks EE, et al. J Biol Chem. 1997, 272(46):29207-11.