应用
1-Methoxy-3-trimethylsiloxy-1,3-butadiene is employed as a reagent in Mannich-Michael reaction for the synthesis of piperidinones and enaminones. As Diels-Alder diene, it is used in the synthesis of pyridones and pyranones, sulfone analogues of griseofulvin (sulfogriseofulvins) and 4H-1-aminopyrroles and 4, 5H-pyrazoles.

备注
Moisture sensitive. Store in cool place. Incompatible with strong oxidizing agents and strong acids.

基本信息

MDL
MFCD00008498

分子式
C₈H₁₆O₂Si

分子量
172.30

沸点
68-69°/14mm

闪点
45°(113°F)

密度
0.890

折射率
1.4555

灵敏度
Keep Cold. Moisture Sensitive.

形态
Liquid

溶解性
Miscible with most organic solvents. Immiscible with water.

Beilstein
1616761

Merck
14,6001

GHS危害和防范说明

GHS符号

Hazard Statements
H226
Flammable liquid and vapour.

Precautionary Statements
P210-P280a-P240-P241-P303+P361+P353-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Wear protective gloves and eye/face protection.Ground/bond container and receiving equipment.Use explosion-proof electrical/ventilating/lighting/ equipment.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
3

包装组
III

危险类别
10
Flammable.

TSCA
否

应用
1-Methoxy-3-trimethylsiloxy-1,3-butadiene is employed as a reagent in Mannich-Michael reaction for the synthesis of piperidinones and enaminones. As Diels-Alder diene, it is used in the synthesis of pyridones and pyranones, sulfone analogues of griseofulvin (sulfogriseofulvins) and 4H-1-aminopyrroles and 4, 5H-pyrazoles.

备注
Moisture sensitive. Store in cool place. Incompatible with strong oxidizing agents and strong acids.

基本信息

MDL
MFCD00008498

分子式
C₈H₁₆O₂Si

分子量
172.30

沸点
68-69°/14mm

闪点
45°(113°F)

密度
0.890

折射率
1.4550

灵敏度
Store under Argon. Keep Cold. Moisture Sensitive. Air Sensitive.

形态
Liquid

溶解性
Miscible with most organic solvents. Immiscible with water.

Beilstein
1616761

Merck
14,6001

GHS危害和防范说明

GHS符号

Hazard Statements
H226
Flammable liquid and vapour.

Precautionary Statements
P210-P280a-P240-P241-P303+P361+P353-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Wear protective gloves and eye/face protection.Ground/bond container and receiving equipment.Use explosion-proof electrical/ventilating/lighting/ equipment.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
3

包装组
III

危险类别
10
Flammable.

安全等级
60
This material and its container must be disposed of as hazardous waste

TSCA
否

基本信息

安全信息

图形或危害标志
危险性说明	H226: Flammable liquid and vapour. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P210: Keep away from – No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof ./ equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P370 + P378: In case of fire: Use sand, CO2 or extinguishing powder for extinction. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P403 + P235: Store in a well-ventilated place. Keep cool. P405: Store locked up. P501: Dispose of contents/container to local regulations.