基本信息

技术规格

物性(参考值)

安全信息

图形或危害标志
信号词	危险
危险性说明	H300 : 吞咽致命。 H413 : 可能对水生生物造成长期持续有害影响。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P273 : 避免释放到环境中。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

运输信息

基本信息

产品描述

Indomethacin是一种非选择性的COX1和COX2的抑制剂，IC50分别为0.1 μg/mL和5 μg/mL。常用于降低发热、减缓疼痛、僵硬和肿胀。

靶点（IC50 & Targe）

COX-1,0.28μM

COX-2,14μM

PDE2

PLA2

体外研究

Indomethacin以剂量依赖性方式抑制一种β-连环蛋白/ TCF响应报道基因的转录。Indomethacin也下调了β-连环蛋白/ TCF转录针对细胞周期蛋白D1。Indomethacin通过调节TCF活动而不破坏β-连环蛋白/ TCF复合物的形成减少β-连环蛋白/ TCF-应答基因的转录。[1]

体内研究

大鼠局灶性脑缺血后，Indomethacin增加所有细胞系的BrdU+细胞并减少小胶质细胞/单核细胞活化。[2] Indomethacin（7.5 毫克/千克，1次注射）在远端空肠和回肠近端产生急性损伤和炎症，在三天内达到最大，一周内完全解决。Indomethacin（每日2次皮下注射）产生一个更广泛的和慢性炎症，持续以活性形式存在于75％的大鼠中至少两周。[3] 在SKH：HR-1-HRBR无毛小鼠中，Indomethacin（4ppm）减少肿瘤增产达78％。[4] Indomethacin（20 毫克/千克，口服）增加胃糜烂的总面积和大鼠的胃粘膜脂质过氧化物的浓度。 Indomethacin增加α-生育酚：血清总胆固醇的比例。 Indomethacin抑制胃粘膜糜烂和脂质过氧化物在胃粘膜的增加，血清α-生育酚的还原的减少。[5]

参考文献

[1] Dihlmann S, et al. Oncogene, 2001, 20(5), 645-653.

[2] Hoehn BD, et al. Stroke, 2005, 36(12), 2718-2724.

[3] Yamada T, et al. Inflammation, 1993, 17(6), 641-662.

[4] Fischer SM, et al. Mol Carcinog, 1999, 25(4), 231-240.

[5] Yoshikawa T, et al. Gut, 1993, 34(6), 732-737.

[6] Mitchell JA, et al. Proc Natl Acad Sci U S A. 1993, 90(24), 1

安全信息

图形或危害标志
提示语	Danger
危险说明	H300
防范说明	P264 P301+P310
UN号码	2811
危险分类	6.1
包装等级	I
WGK	3
RTECS	NL3500000
TSCA	是

应用
It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

备注
Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00057095

EINECS
200-186-5

分子式
C₁₉H₁₆ClNO₄

分子量
357.8

熔点
158-161°

灵敏度
Light Sensitive. Ambient temperatures.

形态
Powder

溶解性
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Beilstein
497341

Merck
14,4968

GHS危害和防范说明

GHS符号

Hazard Statements
H300-H341
Fatal if swallowed.Suspected of causing genetic defects.

Precautionary Statements
P201-P280-P301+P310a-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
II

危险类别
28-68
Very toxic if swallowed.Possible risk of irreversible effects.

安全等级
20-28-36/37-45
When using do not eat or drink.After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).Wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

欧盟危险品标志

RTECS
NL3500000

TSCA
是

产品说明

一般描述

吲哚美辛是环加氧酶1和2的抑制剂。吲哚美辛可对胃肠道、肾脏和大脑产生副作用。吲哚美辛与布洛芬一起使用，可有效治疗患有呼吸窘迫综合征的婴儿的动脉导管未闭(PDA)。吲哚美辛直肠给药可有效治疗内镜下逆行胰胆管造影(ERCP)诱发的胰腺炎。

应用

吲哚美辛已被用于：

• 在人骨髓干细胞的成骨和脂肪形成分化测定中作为培养基补充剂
• 作为牛羊水干细胞(BAFSCs)培养的培养基补充剂
• 抑制T细胞的前列腺素E2(PGE2)生成

包装

10, 25, 100 g in glass bottle

生化/生理作用

环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。

特点和优势

该化合物由 Pfizer开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
该化合物是ADME Tox研究的特色产品。点击此处 ，查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
《受体分类和信号转导》手册的 前列腺素类受体 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Indomethacin drug is extensively employed as a pharmacologic agent to bring about the closure of patent ductus arteriosus (PDA) in premature infants.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Indomethacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.

生化/生理作用

环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0281 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P301 + P310
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。

包装

Unit quantity: 70 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

包装

5, 25, 100 g in glass bottle

生化/生理作用

环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。
用作环氧合酶的非选择性抑制剂 COX1 和 COX2，导致从花生四烯酸合成前列腺素减少。

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P301 + P310
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品说明

一般描述

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Reported to reduce Aβ₄₂ levels independently of COX activity.

包装

10 g in Alu drum

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

其他说明

Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun.281, 483.
Weggen, S., et al. 2001. Nature414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins19, 271.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

基本信息

安全信息

图形或危害标志
危险性说明	H300: Fatal if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.