CAS 383432-38-0; cp-724714

位置：首页 > 资料中心 > 化工字典 > 383432-38-0

CAS:

383432-38-0

分子式:

C₂₇H₂₇N₅O₃

分子量:

469.54

英文名称:

cp-724714

用途:

CP-724714 是HER2/ErbB2抑制剂，IC50为10 nM，比对EGFR，InsR，IRG-1R，PDGFR，VEGFR2，Abl，Src和c-Met的抑制性高640倍。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

C879245

MACKLIN

CP-724714

≥99%

474元/5mg; 854元/10mg;

展开

储存：2-8℃

PZ0335

Sigma-Aldrich

CP724714

≥98% (HPLC)

1117.23元/5 MG; 4498.97元/25 MG;

展开

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC₅₀ value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.

其他说明

CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₇H₂₇N₅O₃
分子量	469.53
MDL编号	MFCD15144738
PubChem化学物质编号	329823846

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
创始人	Pfizer
储存温度	room temp
SMILES string	COCC(NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CC=C(C)N=C4)C(C)=C3)C2=C1)=O
InChI	1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
InChI key	LLVZBTWPGQVVLW-SNAWJCMRSA-N
Gene Information	human ... ERBB2(2064)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9