| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| H794146 | MACKLIN | 和厚朴酚 | 10mM in DMSO | 102元/1ml; | 展开 |
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| H811215 | MACKLIN | 和厚朴酚 | ≥98% (HPLC) | 28元/50mg; 30元/250mg; 57元/1g; 183元/5g; 766元/25g; 2189元/100g; 9250元/500g; | 展开 |
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| H1309 | TCI | Honokiol | >95.0%(GC) | 150元/200MG; 490元/1G; | 展开 |
基本信息 | 纯度/分析方法 | >95.0%(GC) | | 分子式/分子量 | C18H18O2 = 266.34 | | 外观与形状(20℃) | 固体 | | 储存温度 | 0-10℃ | | 应避免的情况 | 加热 | | Reaxys-RN | 1982052 | | PubChem物质ID | 125307566 | | Merck Index (14) | 4742 | | MDL编号 | MFCD00016674 |
技术规格 | Appearance | White to Light yellow to Light orange powder to crystal | | Purity(GC) | min. 95.0 % | | Melting point | 83.0 to 87.0 ℃ |
物性(参考值) 安全信息 | 图形或危害标志 |  | | 信号词 | 危险 | | 危险性说明 | H318 : 造成严重眼损伤。
| | 防范说明 | P280 : 戴防护眼罩/戴防护面具。
P305 + P351 + P338 + P310 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。立即呼叫急救中心/医生。
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| 114705 | J&K | Honokiol | 98%, 来源于厚朴, 抑制 Akt 的活化并增强ERK1/ERK2的磷酸化 | 78元/20MG; 196元/100MG; 941元/1G; | 展开 |
基本信息 | 分子式 | C18H18O2 | | 分子量 | 266.33 | | 熔点 | 83-87 | | MDL编码 | MFCD00016674 | | Beilstein | 1982052 | | Merck | 14,4742 | | 存储条件 | Store at 2-8℃ |
产品描述 Honokiol是木兰的有效成分，抑制Akt磷酸化，且促进ERK1/2磷酸化。Phase 3。 靶点（IC50 & Targe） MEK P-Akt 体外研究 Honokiol作用于黑色素瘤，肉瘤，骨髓瘤，白血病，膀胱癌，肺癌，前列腺癌，口腔鳞状细胞癌和结肠癌细胞系，具有促细胞凋亡的作用效果。Honokiol作用于 SVR肉瘤细胞，有效诱导细胞凋亡。Honokiol处理SVR细胞，降低MAP, akt, 和c-src的磷酸化。另外，Honokiol增强TRAIL调节的凋亡，且通过TRAIL中和抗体可部分废除Honokiol毒性。Honokiol也具有直接的抗血管生成活性， 因为VEGF-VEGFR2的相互作用，Honokiol阻断磷酸化和rac激活[1] 通过激活caspase 8，再激活caspase 9 和3，Honokiol促进CLL细胞凋亡。Honokiol抑制白细胞介素-4调节的CLL细胞生存，也增强Chlorambucil, Fludarabine, 和Cladribine的细胞毒性。[3] Honokiol可以杀死复发患者的骨髓瘤细胞，但是这种剂量不会杀死外周血单个核细胞（PBMCs）。Honokiol 处理，诱导Caspase 3, 7, 8, 和 9，及 PARP裂解。 [2] Honokiol 作用于结肠癌细胞RKO，诱导凋亡。[4]Honokiol 通过调节NF-κB活化途径，增强细胞凋亡，抑制破骨细胞，并抑制入侵。[5] Honokiol可作为一种有效的抗炎试剂，因其具有抑制PI3K/Akt通路的作用，Honokiol具有多能活性。[6] 体内研究 Honokiol处理裸鼠，高效抗SVR肉瘤。[1]Honokiol 作用于小鼠移植瘤，抑制RKO细胞生长。[4] Honokiol 处理小鼠移植瘤，抑制MDA-MD-231乳腺癌细胞生长。[7] 参考文献 [1] Bai X, et al. J Biol Chem, 2003, 278(37), 35501-35507. [2] Ishitsuka K, et al. Blood, 2005, 106(5), 1794-800. [3] Battle TE, et al. Blood, 2005, 106(2), 690-697. [4] Wang T, et al. World J Gastroenterol, 2004, 10(15), 2205-2208. [5] Ahn KS, et al. Mol Cancer Res, 2006, 4(9), 621-633. [6] Kim BH, et al. Acta Pharmacol Sin, 2008, 29(1), 113-122. [7] Wolf I, et al. Int J Oncol, 2007, 30(6), 1529-1537. 安全信息 | 图形或危害标志 |  | | 提示语 | Danger | | 危险说明 | H318
H400
H410 | | 防范说明 | P280
P305+P351+P338 | | UN号码 | 3077 | | 危险分类 | 9 | | 包装等级 | III | | WGK | 3 |
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| 976609 | J&K | Honokiol | 来源于厚朴, 有效含量≥90%, 可溯源至中检院标准品 | 171元/20MG; | 展开 |
基本信息 | 分子式 | C18H18O2 | | 分子量 | 266.33 | | MDL编码 | MFCD00016674 |
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| Y0001290 | | Honokiol | European Pharmacopoeia (EP) Reference Standard | 1574.63元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 和厚朴酚是来自木兰提取物的天然联苯新木脂素。它具有抗血管生成、抗肿瘤和抗焦虑的作用。 包装 Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C18H18O2 | | 分子量 | 266.33 | | MDL编号 | MFCD00016674 | | PubChem化学物质编号 | 329831346 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | −20℃ | | SMILES string | Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O | | InChI | 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 | | InChI key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H318 - H411 | | 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P391 - P501 | | 危险分类 | Aquatic Chronic 2 - Eye Dam. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| H4914 | Sigma-Aldrich | Honokiol | ≥98% (HPLC), powder | 2069.62元/10 MG; 4155.59元/25 MG; | 展开 |
产品说明 一般描述 和厚朴酚具有止痛、抗血栓形成、抗痉挛、抗抑郁、抗微生物和神经保护作用。它调节γ-氨基丁酸(GABAA)的受体。和厚朴酚与增加的出血风险有关。它可防止血小板聚集，保护心肌免于缺血性损害，并抑制室性心律失常。 应用 和厚朴酚已被用于：
- 研究其对hSirt3102-399质粒脱乙酰活性的影响
- 研究其作为抗氧化剂对人卵巢癌细胞(SKOV-3) 和中国仓鼠卵巢癌细胞(CHOK1)的细胞保护作用
- 探索其通过sirt3依赖性的方式对氧化应激和线粒体功能障碍的影响
- 用于侧脑室(ICV) 置管
包装 10, 25 mg in glass bottle 生化/生理作用 和厚朴酚是来自木兰提取物的天然联苯新木脂素。它具有抗血管生成、抗肿瘤和抗焦虑的作用。 特点和优势 这种化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。 基本信息 | 经验(实验)分子式 | C18H18O2 | | 分子量 | 266.33 | | MDL编号 | MFCD00016674 | | PubChem化学物质编号 | 24724501 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | powder | | 储存条件 | desiccated | | 溶解性 | DMSO: 36 mg/mL | | 作用机制 | DNA synthesis | interferes | | 抗生素抗菌谱 | Gram-positive bacteria
neoplastics | | 储存温度 | 2-8℃ | | SMILES string | Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O | | InChI | 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 | | InChI key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H318 - H411 | | 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P391 - P501 | | 危险分类 | Aquatic Chronic 2 - Eye Dam. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| 42612 | Supelco | Honokiol | analytical standard | 2560.15元/25 MG; | 展开 |
产品说明 应用 Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. 生化/生理作用 和厚朴酚是来自木兰提取物的天然联苯新木脂素。它具有抗血管生成、抗肿瘤和抗焦虑的作用。 基本信息 | 经验(实验)分子式 | C18H18O2 | | 分子量 | 266.33 | | MDL编号 | MFCD00016674 | | PubChem化学物质编号 | 329756248 | | NACRES | NA.24 |
产品性质 | 等级 | analytical standard | | 质量水平 | 100 | | 测定 | ≥98.0% (HPLC) | | 保质期 | limited shelf life, expiry date on the label | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | application(s) | food and beverages | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O | | InChI | 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 | | InChI key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H318 - H411 | | 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P391 - P501 | | 危险分类 | Aquatic Chronic 2 - Eye Dam. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| PHL89315 | | Honokiol | phyproof® Reference Substance | 3328.55元/20 MG; | 展开 |
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 生化/生理作用 和厚朴酚是来自木兰提取物的天然联苯新木脂素。它具有抗血管生成、抗肿瘤和抗焦虑的作用。 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息 | 经验(实验)分子式 | C18H18O2 | | 分子量 | 266.33 | | MDL编号 | MFCD00016674 |
产品性质 | 等级 | primary reference standard | | 产品线 | phyproof® Reference Substance | | 测定 | ≥95.0% (HPLC) | | 形式 | powder | | manufacturer/tradename | PhytoLab | | SMILES string | Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O | | InChI | 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 | | InChI key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H318 - H411 | | 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P391 - P501 | | 危险分类 | Aquatic Chronic 2 - Eye Dam. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 384620 | Sigma-Aldrich | Honokiol-CAS 35354-74-6-Calbiochem | A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. | 1977.69元/10 MG; | 展开 |
产品说明 一般描述 A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice. 包装 10 mg in Plastic ampoule
Packaged under inert gas 生化/生理作用 Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Anti-angiogenic, anti-tumor and anxiolytic properties 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Bai, X., et al. 2003. J. Biol. Chem.278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.
Son, H.J., et al. 2000. Planta Med.66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C18H18O2 | | 分子量 | 266.33 | | MDL编号 | MFCD00016674 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
protect from light | | 颜色 | white | | 溶解性 | DMSO: 10 mg/mL
ethanol: soluble | | 运输 | ambient | | 储存温度 | 2-8℃ | | InChI | 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 | | InChI key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H318 - H411 | | 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P391 - P501 | | 危险分类 | Aquatic Chronic 2 - Eye Dam. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 221573 | Fluorochem | 5,3'-Diallyl-2,4'-dihydroxybiphenyl | 95% | 220元/250mg; 440元/1g; 2090元/5g; 8778元/25g; | 展开 |
基本信息 | CAS Number | 35354-74-6 | | MDL Number | MFCD00016674 | | Melting Point | 83-88℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H318: Causes serious eye damage.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H411: Toxic to aquatic life with long lasting effects.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P391: Collect spillage.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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