CAS 341001-38-5; nucleozin

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CAS:

341001-38-5

分子式:

C₂₁H₁₉ClN₄O₄

分子量:

426.85

英文名称:

nucleozin

[4-(2-chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone

1-(2-chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine

用途:

Nucleozin靶向流感A的核蛋白（NP）。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

N879487

MACKLIN

Nucleozin

≥99%

484元/5mg; 780元/10mg;

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储存：2-8℃

N796596

MACKLIN

Nucleozin

96%

408元/25mg;

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储存：-20°C

N2790

Sigma-Aldrich

Nucleozin

≥98% (HPLC), powder

1179.67元/5 MG; 4730.28元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

应用

Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.

生化/生理作用

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.
Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC₅₀ is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

基本信息

经验(实验)分子式	C₂₁H₁₉ClN₄O₄
分子量	426.85
MDL编号	MFCD01426660
PubChem化学物质编号	329818419
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	yellow
溶解性	DMSO: >15 mg/mL
储存温度	2-8℃
SMILES string	Cc1onc(-c2ccccc2)c1C(=O)N3CCN(CC3)c4ccc(cc4Cl)[N+]([O-])=O
InChI	1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChI key	OWXBJAPOSQSWAO-UHFFFAOYSA-N

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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