| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| N801851 | MACKLIN | N-叔丁基-а-苯基硝酮 | 98% | 42元/200mg; 149元/1g; 698元/5g; 2449元/25g; 6688元/100g; | 展开 |
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| B1701 | TCI | N-tert-Butyl-α-phenylnitrone | >98.0%(T)(HPLC) | 680元/1G; 1940元/5G; | 展开 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C11H15NO = 177.25 | | 外观与形状(20℃) | 固体 | | 储存在惰性气体下 | 存放于惰性气体之中 | | 应避免的情况 | 空气 | | Reaxys-RN | 1841513 | | PubChem物质ID | 87564601 | | SDBS (AIST Spectral DB) | 15157 | | MDL编号 | MFCD00008799 |
技术规格 | Appearance | White to Light yellow to Light orange powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Nonaqueous Titration) | min. 98.0 % | | Melting point | 72.0 to 75.0 ℃ |
物性(参考值) |
| 232165 | J&K | N-tert-Butyl-α-phenylnitrone | 98% | 528元/1G; 1748元/5G; 8460元/25G; | 展开 |
基本信息 | 分子式 | C11H15NO | | 分子量 | 177.24 | | 熔点 | 73-77 | | MDL编码 | MFCD00008799 | | Beilstein | 1841513 | | Merck | 13,7129 | | EINECS 编号 | 222-168-6 | | 存储条件 | Freezer -20℃ |
安全信息 | 防范说明 | P260
P262 | | WGK | 3 | | RTECS | TX1760000 | | TSCA | 是 |
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| A17442 | Alfa Aesar | N-tert-Butyl-alpha-phenylnitrone | 97% | 817元/1g; 3504元/5g; 14961元/25g; | 展开 |
应用
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species. 备注
Store in a cool place. Reactive with oxidizing agents. 基本信息 MDL
MFCD00008799 EINECS
222-168-6 分子式
C11H15NO 分子量
177.25 熔点
71-75° 灵敏度
Keep Cold. 形态
Crystalline powder 溶解性
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml). Beilstein
2044028 Merck
14,7056 安全信息 TSCA
是 |
| C17735 | Alfa Aesar | N-tert-Butyl-alpha-phenylnitrone | 98% | 795元/1g; 3426元/5g; 16708元/25g; | 展开 |
基本信息 Ref#
17735 MDL
8799 分子式
C11 H15 N O 分子量
177.25 形态
White cryst powder |
| B7263 | Sigma-Aldrich | N-tert-Butyl-α-phenylnitrone | ≥98% (GC) | 1573.8元/1 G; 5467.1元/5 G; | 展开 |
产品说明 应用 N-叔丁基-α-苯基硝酮已用于： - 用作Dneasy Blood&血液组织缓冲液组分，以保留从人类非致瘤性上皮性乳腺癌(MCF10A)细胞中提取的氧化态DNA
- 用作微胶质(MG)细胞系活性氧(ROS)自由基清除试剂
- 衰减不稳定口腔鳞状细胞癌(GU-OSCC)中的成纤维细胞衰老
包装 1, 5 g in glass bottle 生化/生理作用 N-叔丁基-α-苯基硝酮(PBN)是一种常用的自由基自旋捕获剂。已有研究表明，PBN具有自由基清除活性以及抑制环氧合酶-2活性的能力，因此，它可以减少兔皮质中栓子诱导的脑微梗死的数量并预防肿瘤形成。据报道，PBN可抑制诱导型一氧化氮合酶(iNOS)，从而防止一氧化氮(NO)过量产生。 PBN以100 mg/kg腹腔注射，可减少氟替尔诱导大鼠癫痫持续状态中的黑质网状部坏死。它可以预防癫痫动物模型中某些类型的创伤后致癫痫事件。已有研究发现，大鼠的PBN致死剂量约为100 mg/100 g体重(0.564 mmol/100Å g)。 基本信息 | 线性分子式 | C6H5CH=N(O)C(CH3)3 | | 分子量 | 177.24 | | Beilstein | 2044028 | | EC 号 | 222-168-6 | | MDL编号 | MFCD00008799 | | PubChem化学物质编号 | 24891981 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (GC) | | 形式 | powder | | 颜色 | white | | mp | 73-74 ℃ (lit.) | | 溶解性 | DMSO: soluble | | 储存温度 | −20℃ | | SMILES string | CC(C)(C)[N+](\[O-])=C\c1ccccc1 | | InChI | 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9- | | InChI key | IYSYLWYGCWTJSG-XFXZXTDPSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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| 80126 | Supelco | N-tert-Butyl-α-phenylnitrone | for ESR-spectroscopy | 3475.45元/1 G; | 展开 |
产品说明 应用 用 EPR 自旋捕捉技术测定类胡萝卜素清除速率常数时，用 N-叔丁基苯基硝酮作为自旋捕捉剂。该试剂有助于获得六线 ESR 谱和超精细耦合常数，使用电子自旋共振光谱和液相色谱质谱法证实尿酸和过氧亚硝基中存在碳基自由基。 生化/生理作用 N-叔丁基-α-苯基硝酮(PBN)是一种常用的自由基自旋捕获剂。已有研究表明，PBN具有自由基清除活性以及抑制环氧合酶-2活性的能力，因此，它可以减少兔皮质中栓子诱导的脑微梗死的数量并预防肿瘤形成。据报道，PBN可抑制诱导型一氧化氮合酶(iNOS)，从而防止一氧化氮(NO)过量产生。 PBN以100 mg/kg腹腔注射，可减少氟替尔诱导大鼠癫痫持续状态中的黑质网状部坏死。它可以预防癫痫动物模型中某些类型的创伤后致癫痫事件。已有研究发现，大鼠的PBN致死剂量约为100 mg/100 g体重(0.564 mmol/100Å g)。 基本信息 | 线性分子式 | C6H5CH=N(O)C(CH3)3 | | 分子量 | 177.24 | | Beilstein | 2044028 | | EC 号 | 222-168-6 | | MDL编号 | MFCD00008799 | | PubChem化学物质编号 | 329768721 | | NACRES | NA.21 |
产品性质 | 等级 | for ESR-spectroscopy | | 质量水平 | 100 | | 测定 | ≥99.5% (HPLC) | | mp | 72-74 ℃
73-74 ℃ (lit.) | | 溶解性 | chloroform: 50 mg/mL, clear, colorless | | 储存温度 | −20℃ | | SMILES string | CC(C)(C)[N+](\[O-])=C\c1ccccc1 | | InChI | 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9- | | InChI key | IYSYLWYGCWTJSG-XFXZXTDPSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 8.41179 | Sigma-Aldrich | N-tert-Butyl-α-phenylnitrone | for synthesis | 745.57元/1 G; | 展开 |
产品说明 分析说明 Assay (HPLC, area%): ≥ 98.0 % (a/a)
Melting range (lower value): ≥ 71 °C
Melting range (upper value): ≤ 73 °C
Identity (IR): passes test 基本信息 | 经验(实验)分子式 | C11H15NO | | 分子量 | 177.24 | | MDL编号 | MFCD00008799 | | EC索引号 | 222-168-6 |
产品性质 | 质量水平 | 200 | | 测定 | ≥98.0% (HPLC) | | mp | 71-73 ℃ | | InChI | 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3 | | InChI key | IYSYLWYGCWTJSG-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 203995 | Sigma-Aldrich | N-tert-Butyl-α-phenylnitrone-CAS 3376-24-7-Calbiochem | Most commonly-used free radical trap. | 1107.98元/500 MG; | 展开 |
产品说明 一般描述 Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species. 包装 500 mg in Plastic ampoule 生化/生理作用 Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Free radical trap 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use. 其他说明 Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C11H15NO | | 分子量 | 177.24 | | MDL编号 | MFCD00008799 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (GC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze | | 颜色 | white | | 溶解性 | DMSO: 10 mg/mL
water: 20 mg/mL
chloroform: 50 mg/mL | | 运输 | ambient | | 储存温度 | −20℃ | | InChI | 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3 | | InChI key | IYSYLWYGCWTJSG-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 500296 | Fluorochem | N-tert-Butyl-a-phenylnitrone | 95% | 858元/1g; | 展开 |
基本信息 | CAS Number | 3376-24-7 | | MDL Number | MFCD00008799 | | Melting Point | 74℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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