产品说明

一般描述

An uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC₅₀ = 1.8 µM), PTP1B (IC₅₀ = 2.5 µM), PTP-ε (IC₅₀ = 8.4 µM), PTP-Meg-2 (IC₅₀ = 13 µM), PTP-ς (IC₅₀ = 20 µM), PTP-β (IC₅₀ = 6.4 µM), and PTP-µ (IC₅₀ = 6.7 µM).
An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP; IC₅₀ = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-ς, PTP-β, and PTP-µ, respectively).

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product competes with ATP.
Primary Target
SHP-2
Target IC₅₀: 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ, respectively
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Huang, P., et al. 2003. Bioorg. Med. Chem.11, 1835.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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