CAS 315706-13-9; insolution eif4e/eif4g interaction inhibitor, 4egi-1-cas 315706-13-9-calbiochem

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CAS:

315706-13-9

分子式:

C₁₈H₁₂Cl₂N₄O₄S

分子量:

451.28

英文名称:

insolution eif4e/eif4g interaction inhibitor, 4egi-1-cas 315706-13-9-calbiochem

eif4f inhibitor i, 2-((4-(3,4-dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid

2-((4-(3,4-dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eif4f inhibitor i

用途:

4EGI-1是通过结合eIF4E，竞争性的作用于eIF4E/eIF4G相互作用的抑制剂，其KD值为25 μM。4EGI-1扰乱eIF4F 复合体，在体外实验中抑制Cap 介导的翻译。4EGI-1在Jurkat细胞中有促凋亡活性，在A549肺癌细胞中，能够有效抑制细胞生长，其IC50值约为6μM。[1]在人类肺癌细胞中，4EGI-1通过诱导DR5和下调c-FLIP，cap依赖性蛋白质翻译的单独抑制而增加TRAIL诱导的细胞凋亡。[2]此外，在慢性淋巴细胞癌中，4EGI-1通过 cap依赖和非依赖的机制来恢复对ABT-737的敏感性。[3]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

E872984

MACKLIN

4EGI-1

99%

199元/1mg; 738元/5mg;

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储存：-20℃
状态：浅黄色到黄色到卡其色固体

E792374

MACKLIN

4EGI-1

10mM in DMSO

710元/1ml;

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储存：-20°C

324519

Sigma-Aldrich

InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

2165.23元/5 MG;

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产品说明

一般描述

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC₅₀ ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
eIF4E

警告

Toxicity: Irritant (B)

外形

A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他说明

Gkogkas, C.G., et al. 2012. Nature493, 371.
Moerke, N. J., et al. 2007. Cell128, 257.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₈H₁₂Cl₂N₄O₄S
分子量	451.28

产品性质

测定	≥95% (sum of two isomers, HPLC)
质量水平	100
形式	liquid
效能	25 μM K_i
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
运输	dry ice
储存温度	−70℃

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

324517

Sigma-Aldrich

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for P

3543.57元/10 MG;

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产品说明

一般描述

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC₅₀ ~25 µM).
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC₅₀ = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.