CAS 315702-99-9; stf-62247

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产品名称

规格

包装、参考价格

详情

S794298

MACKLIN

STF-62247

10mM in DMSO

198元/1ml;

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储存：-20°C

S854809

MACKLIN

STF-62247

98%

254元/5mg; 612元/25mg; 1224元/100mg;

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储存： -20°C
状态：粉末

S7448

Sigma-Aldrich

STF-62247

≥98% (HPLC), solid

1619.17元/5 MG;

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产品说明

应用

STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

包装

5 mg in glass bottle

生化/生理作用

STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.
STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.¹

基本信息

经验(实验)分子式	C₁₅H₁₃N₃S
分子量	267.35
MDL编号	MFCD01121974
PubChem化学物质编号	329824583
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: soluble 26 mg/mL H₂O: insoluble
储存温度	room temp
SMILES string	Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1
InChI	1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChI key	KATNUHQNJGNLPW-UHFFFAOYSA-N

安全信息

危险声明	H413
预防措施声明	P273 - P501
危险分类	Aquatic Chronic 4
储存分类代码	11 - Combustible Solids
WGK	WGK 2
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

189497

Sigma-Aldrich

Autophagy Inducer, STF-62247-CAS 315702-99-9-Calbiochem

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

1123.01元/10 MG;

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产品说明

一般描述

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC₅₀ = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Toxic (F)

其他说明

Turcotte, S., et al. 2008. Cancer Cell14, 90.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₅H₁₃N₃S
分子量	267.35
MDL编号	MFCD01121974

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	beige
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

危险声明	H413
预防措施声明	P273 - P501
危险分类	Aquatic Chronic 4
储存分类代码	11 - Combustible Solids
WGK	WGK 2

521408

Fluorochem

4-(Pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine

95+%

6446元/250mg; 15994元/1g;

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基本信息

CAS Number	315702-99-9
MDL Number	MFCD01121974