CAS 1527503-11-2; 5′-methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3h]indol]-2′-amine; a-366

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货号

品牌

产品名称

规格

包装、参考价格

详情

A793761

MACKLIN

A-366

10mM in DMSO

745元/1ml;

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储存：-20°C

A873874

MACKLIN

A-366

98%

32元/1mg; 251元/10mg; 849元/50mg; 2539元/250mg;

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储存：-20℃
状态：白色到米黄色粉末

C46807

Alfa Aesar

A-366

95%

20286元/100mg;

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基本信息

分子式
C19 H27 N3 O2

分子量
329.44

SML1410

Sigma-Aldrich

A-366

≥98% (HPLC)

1396.09元/5 MG; 4498.97元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC₅₀ values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary on the Chemical Probes Portal website.

基本信息

经验(实验)分子式	C₁₉H₂₇N₃O₂
分子量	329.44
MDL编号	MFCD28133403
PubChem化学物质编号	329825857
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4
InChI	1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChI key	BKCDJTRMYWSXMC-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H400
预防措施声明	P273 - P391
危险分类	Aquatic Acute 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable