| CAS: | 152121-53-4 | ||
| 分子式: | C20H13FN4O2 | ||
| 分子量: | 360.34 | ||
| 中文名称: |
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| 用途: | PD 169316 是一种高效，细胞透过的，有选择性的 p38 MAP kinase 抑制剂，IC50 值为 89 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| P860866 | MACKLIN | PD 169316 | >97% | 258元/10mg; 998元/50mg; 1694元/100mg; 2613元/250mg; 6348元/1g; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：浅黄色到棕色粉末到晶体 折射率：yellow solid | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| P2532 | TCI | PD 169316 | >98.0%(HPLC) | 390元/10MG; 1690元/50MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 618810 | J&K | PD 169316 | 98%, 一种高效, 细胞透过的, 有选择性的 p38 MAP kinase 抑制剂, IC50 值为 89 nM | 1202元/10MG; 3976元/50MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
基本信息
产品描述 PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71. 靶点（IC50 & Targe） p38 体外研究 PD169316 (10 μM) inhibits TGFβ and Activin A, but not BMP4 signaling in CaOV3 cells. PD169316 (0.2-20 μM) inhibits TGFβ-induced Smad2 nuclear translocation, Smad7 mRNA induction, and reporter gene activity in CaOV3 cells[1]. PD169316 (10 μM) shows a significantly increased rate of proliferation in Nestin knockdown cells, and can rescue the effect of Nestin knockdown on cell viability in the absence of EGF[2]. PD169316 significantly inhibits p38 MAP kinase activity with no significant change in ERK activity in PC12 cells. PD169316 (10 μM) blocks apoptosis induced by trophic factor withdrawal in differentiated PC12 cells[3].PD169316 (10 μM, 30 min) selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. Increased phospho p-38 levels in the presence of PD169316 are most likely due to blockade of negative feedback loop of dephosphorylation of p38 MAPK by MAPK phosphatases[4].Western Blot Analysis[1] 体内研究 PD169316 (1 mg/kg, intramuscular injection every day for 14 consecutive days) shows antiviral activity in a suckling mouse model[5].Animal Model: EV71-challenged suckling mouse model (7-day-old Kunming mice)[5].Dosage: 1 mg/kg.Administration: Intramuscular injection every day for 14 consecutive days.Result: Showed antiviral activity. 参考文献 [1]. Fu Y, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7. [2]. Hu W, et al. Suppression of Nestin reveals a critical role for p38-EGFR pathway in neural progenitor cell proliferation. Oncotarget. 2016 Dec 27;7(52):87052-87063. [3]. Kummer JL, et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997 Aug 15;272(33):20490-4. [4]. Khan JA, et al. p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization. Mol Endocrinol. 2011 Oct;25(10):1710-24. [5]. Zhang Z, et al. PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71. Virology. 2017 Aug;508:150-158. 安全信息
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| 513030 | Sigma-Aldrich | PD 169316-CAS 152121-53-4-Calbiochem | A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). | 2340.22元/1 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines. 包装 1 mg in Plastic ampoule 生化/生理作用 Cell permeable: yes 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C. 其他说明 Nath, R., et al. 2001. Cell Mol. Biol. Lett.6, 173. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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| P9248 | Sigma-Aldrich | PD 169316 | ≥98% (HPLC), solid | 2328.49元/5 MG; 7425.04元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 PD 169316是一种吡啶基咪唑化合物。它是p38丝裂原活化蛋白激酶的一种潜在抑制剂。它也对转化生长因子β(TGFβ)的信号转导进行抑制，特别是在人卵巢癌细胞中。 应用 PD 169316已被用于抑制人肝细胞中的p38酶。它已被用于在培养基中促进胚状体的分化。 包装 5, 25 mg in glass bottle 生化/生理作用 有效的细胞通透型选择性p38激酶抑制剂(IC50 = 89 nM)。 特点和优势 该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。 基本信息
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| M02298 | Fluorochem | PD 169,316 | >98% | 11462元/25mg; 33242元/100mg; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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