CAS 152095-12-0; dp44mt

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CAS:

152095-12-0

分子式:

C₁₄H₁₅N₅S

分子量:

285.37

英文名称:

dp44mt

2-(di-2-pyridinylmethylene)-n,n-dimethyl-hydrazinecarbothioamide

di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone

用途:

Dp44mT是一种铁离子螯合剂，表现出抗肿瘤活性。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

D872601

MACKLIN

Dp44mT

97%

125元/5mg; 367元/25mg; 832元/100mg; 2145元/500mg;

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储存：-20℃
状态：浅黄色到黄色到橙色粉末

D794938

MACKLIN

Dp44mT

10mM in DMSO

185元/1ml;

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储存：-20°C

SML0186

Sigma-Aldrich

Dp44mT

≥98% (HPLC)

991.46元/5 MG; 3784.9元/25 MG;

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产品说明

应用

Dp44mT may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer.
Dp44mT is an iron chelator that works as a selective anticancer agent. As other iron chelators it can serve as a therapeutic adjunct to doxorubicin treatment. Additionally Dm44mT possess DNA-damaging activity. It appears that that activity is mediated by top2a inhibition.

特点和优势

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

注意

Material appears to be unstable in solution; make solutions immediately before use.

基本信息

经验(实验)分子式	C₁₄H₁₅N₅S
分子量	285.37
MDL编号	MFCD20527329
PubChem化学物质编号	329825215
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	yellow to orange
溶解性	DMSO: ≥5 mg/mL
创始人	Bayer
储存温度	2-8℃
SMILES string	CN(C)C(=S)N\N=C(\c1ccccn1)c2ccccn2
InChI	1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)
InChI key	XOBIGRNRXCAMJQ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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