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CAS: 13220-33-2
分子式: C5H11NO
分子量: 101.15
沸点: 50℃(1 to
中文名称: 
1-甲基-3-吡咯烷醇
N-甲基吡咯烷醇
N-甲基氮杂环戊醇
3-羟基-1-甲基四氢吡咯
英文名称: 
1-methyl-3-pyrrolidinol
3-Hydroxy-N-methylpyrrolidine
N-Methyl-pyrrolidinyl alcohol
性质描述: 无色透明液体。沸点77℃(2.13kPa),50-52℃(0.133kPa),相对密度0.921(20/4℃),折光率1.4660。闪点70℃。易溶于水,溶于醇、醚和苯。
生产方法: 由1,2,4-丁三醇经氯化、环合而得。1.氯化将丁三醇和冰醋酸加入反应锅内,搅拌加热至100℃左右,通入干燥的氯化氢气体,在90-100℃间反应30h,当尾气开始出现大量氯化氢时,检查反应终点,停通氯化氢。冷却后出料,用饱和碳酸钠溶液洗涤,进行减压蒸馏,收集120-135℃(12.7-13.3kPa)馏分,即得1,4-二氯-2-丁醇,为油状物,收率50-60%。2.环合将1,4-二氯-2-丁醇和甲胺水溶液加入环合锅内,密闭加热至120℃,搅拌反应10h。冷却,加固体氢氧化钠,滤去析出的无机盐。分取油层进行减压蒸馏,收集76-85℃(2.13kPa)馏分,即为成品。水层用苯提取还能得到一部分1-甲基-3-吡咯烷醇。收率60%左右。每吨产品(含量80-90%)需消耗1,4-二氯-2-丁醇(90%)约2330kg,一甲胺(30%)5200kg。
用途: 用作药品中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
M813354MACKLIN1-甲基-3-吡咯烷醇97%35元/1g;   106元/5g;   517元/25g;   1870元/100g;   展开
储存:室温,易燃物区域
状态:无色到浅黄色到黄色到棕色液体
折射率:n20/D 1.464(lit.)
M2115TCI1-Methyl-3-pyrrolidinol>97.0%(T)290元/5G;   990元/25G;   展开

基本信息

纯度/分析方法>97.0%(T)
分子式/分子量C5H11NO = 101.15
外观与形状(20℃)液体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气,湿气 (吸湿)
Reaxys-RN1101
MDL编号MFCD00003176

技术规格

AppearanceColorless to Yellow to Orange clear liquid
Purity(GC)min. 97.0 %
Purity(Nonaqueous Titration)min. 95.0 %

物性(参考值)

沸点75 ℃/12 mmHg
闪点71 ℃
比重0.99
折射率1.46

安全信息

信号词警告
危险性说明H227 : 可燃液体。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P403 + P235 : 存放在通风良好的地方。保持低温。
205073J&K1-Methyl-3-pyrrolidinol97%145元/1g;   418元/5g;   展开

基本信息

分子式C5H11NO
分子量101.15
沸点50-52
闪点71
密度0.921
折光率(n20D)1.4640
MDL编码MFCD00003176
EINECS 编号236-189-3

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
TSCA
355403J&K1-Methyl-3-pyrrolidinol97%, 水分::≤0.3%174元/1G;   495元/5G;   展开

基本信息

分子式C5H11NO
分子量101.15
沸点50-52
闪点71
密度0.921
折光率(n20D)1.4640
MDL编码MFCD00003176
EINECS 编号236-189-3

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
TSCA
H28122Alfa Aesar3-Hydroxy-1-methylpyrrolidine97%1707元/1g;   7131元/5g;   展开

基本信息

MDL
MFCD00003176

EINECS
236-189-3

分子式
C5H11NO

分子量
101.15

沸点
50-52°/1mm

闪点
71°(160°F)

密度
0.921

折射率
1.464

形态
Liquid

GHS危害和防范说明

GHS符号

Hazard Statements
H227-H315-H319-H335
Combustible liquid.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P210e-P261-P280a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

TSCA

M79506Sigma-Aldrich1-Methyl-3-pyrrolidinol95%410.83元/1 G;   609.28元/5 G;   展开

基本信息

经验(实验)分子式C5H11NO
分子量101.15
EC 号236-189-3
MDL编号MFCD00003176
PubChem化学物质编号24897205
NACRESNA.22

产品性质

质量水平100
测定95%
折射率n20/D 1.464 (lit.)
bp50-52 ℃/1 mmHg (lit.)
密度0.921 g/mL at 25 ℃ (lit.)
SMILES stringCN1CCC(O)C1
InChI1S/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3
InChI keyFLVFPAIGVBQGET-UHFFFAOYSA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)159.8 °F - closed cup
闪点(C)71 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type ABEK (EN14387) respirator filter
040009Fluorochem3-Hydroxy-1-methylpyrrolidine97%286元/1g;   858元/5g;   3256元/25g;   9922元/100g;   展开

基本信息

CAS Number13220-33-2
MDL NumberMFCD00003176
Boiling Point192.2℃
Density0.921

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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