| CAS: | 1320288-17-2 | ||
| 分子式: | C36H59N7O2 | ||
| 分子量: | 621.9 | ||
| 英文名称: |
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| 用途: | UNC0646是G9a选择性抑制剂，IC50为6 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| U883253 | MACKLIN | UNC0646 | ≥99% | 462元/5mg; 889元/10mg; 1177元/25mg; | 展开 | ||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||
| 1834957 | J&K | UNC0646 | 98%, 是G9a选择性抑制剂, IC50为6 nM | 707元/5MG; 998元/10MG; | 展开 | ||||||||||||||||||||||||||||
基本信息
产品描述 UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM. IC50 value: 6 nM [1] Target: G9a UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases. 参考文献 [1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50. | |||||||||||||||||||||||||||||||||
| SML0633 | Sigma-Aldrich | UNC0646 | ≥98% (HPLC) | 1445.69元/5 MG; 5852.13元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 UNC0646 is potent, selective inhibitor of the methyltransferase G9a, which catalyzes lysine-methylation of histones, and nonhistone proteins including p53. 基本信息
产品性质
安全信息
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