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CAS: 132-69-4
分子式: C19H23N3O·HCl
分子量: 345.86
中文名称: 
盐酸苄达明
消炎灵
苄吲胺唑
盐酸炎痛静
1-苄基-3-[3-(二甲氨基)丙氧基]-1H-吲唑盐酸盐
英文名称: 
1-Benzyl-3-[3-(Dimethylamino)Propoxy]-1H-Indazole Hydrochloride
Iodolin
1-benzyl-3-(3-(dimethylamino)propoxy)-1h-indazol monohydrochloride
1-benzyl-3-(3-(dimethylamino)propoxy)-1h-indazole hydrochloride
1-benzyl-3-gamma-dimethylaminopropoxy-1h-indazole hydrochloride
n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanamin hydro
af 864
benalgin
benzidamine hydrochloride
benzindamine hydrochloride
benzydamine hydrochloride
benzyrin
difflam
dorinamin
enzamin
epirotin
imotryl
indolin
ririlim
riripen
salyzoron
tamas
tantum
verax
1-Benzyl-3-(3-[dimethylamino]propoxy)-1H-indazole
展开更多英文名
性质描述: 白色结晶性粉末。熔点160℃,易溶于水、乙醇、氯仿,难溶于乙醚。无臭,味辛辣。
生产方法: 以邻氨基苯甲酸为原料,经重氮化、还原、环合、烃化、缩合、成盐等化学反应生成苄达明。具体操作如下:(1)重氮化 边搅拌边将邻氨基苯甲酸加入一定量水中,加浓盐酸,使反应物溶解,再加盐酸使结晶析出。冷至3℃以下,缓缓滴加亚硝酸钠水溶液,温度不超过3℃,继续搅拌,得透明茶色重氮盐溶液。(2)还原 在10℃以下,将重氮盐溶液滴入二氧化硫饱和溶液中,静置后加浓盐酸,搅拌下有结晶析出,冷至5℃以下,放置、过滤、抽干得邻肼基苯甲酸盐酸盐。(3)环合 将还原物以及水、盐回流30分钟、浓缩、趁热用碳酸钠中和至pH为7,放置,过滤、水洗、干燥,得3-羟基吲哒唑。(4)烃化 将环合物及无水乙醇、氢氧化钠加热回流,冷后过滤,滤液冷冻过夜析出结晶,过滤、干燥,即得1-苄基-3-羟基吲哒唑。(5)缩合 将烃化物、二甲苯及切碎的金属钠加热回流,边搅拌边升温至金属钠融化,有白色气体产生。停止加热,反应物变稠至糊状,滴加二甲氨基氯丙烷与甲苯的混合液,滴完后继续回流反应。放冷、过滤、用二甲苯洗。将滤液与洗液合并,用稀盐酸萃取,加液碱,析出油层,以无水硫酸钠干燥。此即为苄达明游离碱,精制后按常法制成盐酸盐。
用途: 本品为非特异性消炎药物,具有消炎,解热、镇痛作用。对因炎症引起的疼痛有效。抗炎作用与保泰松相似或稍强。本品尚有罂粟碱样解痉作用。常用于手术及外伤所致的各种炎症及关节炎、气管炎、咽炎等。可与抗菌素或磺胺类合用疗效更好。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
B797969MACKLIN盐酸苄达明10mM in DMSO277元/1ml;   展开
储存:-20°C
B833834MACKLIN盐酸苄达明98%34元/1g;   89元/5g;   249元/25g;   746元/100g;   3146元/500g;   展开
储存:2~8°C
状态:白色或灰白色粉末
B3751TCIBenzydamine Hydrochloride>97.0%(T)(HPLC)305元/5G;   855元/25G;   展开

基本信息

纯度/分析方法>97.0%(T)(HPLC)
分子式/分子量C19H23N3O・HCl = 345.87
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
相关CAS RN642-72-8
Reaxys-RN4282836
PubChem物质ID160871060
Merck Index (14)1122
MDL编号MFCD00078957

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 97.0 area%
Purity(Argentometric Titration)min. 97.0 %
Melting point157.0 to 162.0 ℃

物性(参考值)

熔点160 ℃
水溶性可溶

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护眼罩/戴防护面具。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#NK7875000
B5524SupelcoBenzydamine Hydrochlorideanalytical standard761.09元/5 G;   展开

产品说明

应用

有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务。

包装

5 g in poly bottle

基本信息

经验(实验)分子式C19H23N3O · HCl
分子量345.87
EC 号205-076-0
MDL编号MFCD00078957
PubChem化学物质编号329773263
NACRESNA.24

产品性质

等级analytical standard
质量水平200
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)forensics and toxicology
pharmaceutical (small molecule)
veterinary
格式neat
储存温度2-8℃
SMILES stringCl.CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13
InChI1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
InChI keyHNNIWKQLJSNAEQ-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
BP610Benzydamine HydrochlorideBritish Pharmacopoeia (BP) Reference Standard1651.44元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C19H23N3O · HCl
分子量345.87
EC 号205-076-0
MDL编号MFCD00078957
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCl.CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13
InChI1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
InChI keyHNNIWKQLJSNAEQ-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
375843Fluorochem{3-[(1-Benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine hydrochloride97%(HPLC)(T)220元/1g;   682元/5g;   2024元/25g;   5456元/100g;   展开

基本信息

CAS Number132-69-4
MDL NumberMFCD00078957
Melting Point160℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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