CAS 1315330-17-6; tl02-59

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CAS:

1315330-17-6

分子式:

C₃₂H₃₄F₃N₅O₄

分子量:

609.64

英文名称:

tl02-59

3-[(6,7-dimethoxy-4-quinazolinyl)oxy]-n-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide

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货号

品牌

产品名称

规格

包装、参考价格

详情

D727170

MACKLIN

3-((6,7-二甲氧基喹唑啉-4-基)氧基)-N-(4-((4-乙基哌嗪-1-基)甲基)-3-(三氟甲基)苯基)-4-甲基苯甲酰胺

99%

179元/1mg; 451元/5mg; 675元/10mg;

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储存：2-8°C, 干燥

SML3202

Sigma-Aldrich

TL02-59

≥98% (HPLC)

978.44元/5 MG; 3943.82元/25 MG;

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产品说明

生化/生理作用

TL02-59 is a potent inhibitor of Fgr kinase, a Src-family kinase expressed in myeloid cells and associated with acute myelogenous leukemia (AML). It exhibited an IC50 value of 0.03 nM for Fgr, 0.10 nM for related Src-family kinase Lyn, with >1000-fold less potency for all other kinases tested. TL02-59 given orally in a mouse xenograft model of AML was able to eliminate spleen and peripheral blood leukemic cells and significantly reduce bone marrow engraftment.

基本信息

经验(实验)分子式	C₃₂H₃₄F₃N₅O₄
分子量	609.64
MDL编号	MFCD29991221

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	O=C(NC1=CC(C(F)(F)F)=C(CN2CCN(CC)CC2)C=C1)C3=CC(OC4=C(C=C(C(OC)=C5)OC)C5=NC=N4)=C(C)C=C3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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