CAS 1315323-00-2; pyr10

CAS:

1315323-00-2

分子式:

C₁₈H₁₃F₆N₃O₂S

分子量:

449.37

英文名称:

pyr10

n-[4-[3,5-bis(trifluoromethyl)-1h-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide

用途:

Pyr10是一种新型TRPC3选择性抑制剂, 作用于转染YFP-TRPC3的HEK293细胞, 抑制ROCE, IC50为0.72 uM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

P883277

MACKLIN

Pyr10

≥99%

1554元/10mg; 2631元/25mg; 4472元/50mg;

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储存：2-8℃

SML1243

Sigma-Aldrich

Pyr10

≥98% (HPLC)

1117.23元/5 MG; 4498.97元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3. Pyr10 blocks carbachol-induced calcium entry into TRPC3-transfected HEK293 cells (IC₅₀ = 0.72 μM), with significantly lower activity against STIM1/Orai1 mediated release of calcium from endoplasmic reticulum (store operated calcium entry) in BRL-2H3 cells (IC₅₀ = 13.08 μM).

基本信息

经验(实验)分子式	C₁₈H₁₃F₆N₃O₂S
分子量	449.37
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable