CAS 1169562-71-3; xl413 hydrochloride

CAS:

1169562-71-3

分子式:

C₁₄H₁₃Cl₂N₃O₂

分子量:

326.18

英文名称:

xl413 hydrochloride

bms-863233

(S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3h)-one hydrochloride

xl-413

用途:

XL413 (BMS-863233) 是强效的选择性的cell division cycle 7 homolog (CDC7) kinase抑制剂，IC50为3.4 nM,其选择性分别超过 CK2, Pim-1 和pMCM2选择性的 63-, 12-和35-倍。 Phase 1/2。在MDA-MB-231T和Colo-205细胞系中，XL413抑制MCM2的CDC7特异磷酸化作用。XL413也会抑制Colo-205细胞中的细胞增殖，降低细胞活性，并激发胱天蛋白酶3/7的活性。此外，XL413导致S期进展被改变，随后引起细胞凋亡。[1]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

X873123

MACKLIN

XL413 (BMS-863233)

99%

1098元/5mg;

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储存：-20℃
状态：粉末

X795045

MACKLIN

XL413 (BMS-863233)

10mM in Water

891元/1ml;

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储存：-20°C

SML1401

Sigma-Aldrich

XL413 hydrochloride

≥98% (HPLC)

1966.13元/5 MG; 6476.67元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC₅₀ of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.

基本信息

经验(实验)分子式	C₁₄H₁₂ClN₃O₂ · xHCl
分子量	289.72 (free base basis)
PubChem化学物质编号	329825849
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: 5 mg/mL, clear
储存温度	−20℃
SMILES string	ClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C
InChI	1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1
InChI key	UYBMDYGAVMHMGF-FVGYRXGTSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310 + P330
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable