| 包装 | 价格 | |
| 5MG | 47元 | 留言咨询 |
| 10MG | 87元 | 留言咨询 |
产品描述
PD153035是一种特定的、有效的EGFR抑制剂，Ki值为5.2 pM。
靶点（IC50 & Targe）
EGFR
体外研究
PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and cbonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF can be completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor[1].
参考文献
[1] Bos M, et al. Clin Cancer Res. 1997, 3(11):2099-106.
[2] Fry DW, et al. Science. 1994, 265(5175):1093-5.
