Technical Note:

1. The NOYORI catalysts are a ruthenium-based system containing a phosphine and 1 2-diamine ligand. The catalysts are used in the highly- efficient, enantio and diastereoselective hydrogenation of simple ketones, usually under the mild conditions of room temperature and 1-10 atm of hydrogen pressure.

References:

1.J.Org. Chem.. 1996.61.4872.

2. Angew. Chem. Int. Ed.. 2001. 40, 40 (review article).

3. J. Am. Chem. Soc.. 1998, 120, 13529.

4. Angew. Chem. Int. Ed.. 1999, 38, 495.