产品介绍 基因名： GALNT13 产品别名： GalNAc-T13； GALNT13； polypeptide N-acetylgalactosaminyltransferase 13； polypeptide N-acetylgalactosaminyltransferase 13； polypeptide N-acetylgalactosaminyltransferase 13； GalNAc transferase 13； UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13； UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)； polypeptide GalNAc transferase 13； polypeptide N-acetylgalactosaminyltransferase 13 variant delta39bpEx9； polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx2-7； polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx6 delta39bpEx9； polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx6 deltaEx8 delta39bpEx9； polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx8； polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx9； pp-GaNTase 13； protein-UDP acetylgalactosaminyltransferase 13； 背景信息： The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T13 (Polypeptide N-acetylgalactosaminyltransferase 13), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, is a 556 amino acid protein that displays much stronger enzymatic activity than GalNAc-1 towards GalNAc transfer to mucin peptides such as Muc5a and Muc7. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. With specific expression in the central nervous system, GalNAc-T13 may be responsible for the synthesis of Tn antigen in neuronal cells, which is a universal carcinoma marker on malignant cells. 标签：His-tag |
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