产品介绍 基因名： CBLL1 产品别名： HAKAI； RNF188； CBLL1； Cbl proto-oncogene like 1； Cbl proto-oncogene like 1； E3 ubiquitin-protein ligase Hakai； Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1； Cbl proto-oncogene like 1, E3 ubiquitin protein ligase； Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1； E-cadherin binding protein E7； RING finger protein 188； RING-type E3 ubiquitin transferase Hakai； c-Cbl-like protein 1； casitas B-lineage lymphoma-transforming sequence-like protein 1； 上皮钙粘附分子结合蛋白E7； 背景信息： CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions. 标签：His-tag |
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