试剂仪器设备原料
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蛋白质/抗原/多肽 >> 重组蛋白
重组神经元突触膜胞外分泌调节蛋白2
重组神经元突触膜胞外分泌调节蛋白2图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:重组调节突触膜胞吐蛋白2(RIMS2)
Recombinant RIMS2
产品介绍
基因名:

RIMS2


产品别名:

CRSDS; OBOE; RAB3IP3; RIM2; RIMS2; regulating synaptic membrane exocytosis 2; regulating synaptic membrane exocytosis 2; regulating synaptic membrane exocytosis protein 2; RAB3 interacting protein 3; Rab3-interacting protein; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; rab-3-interacting molecule 2; rab-3-interacting protein 3; rab3-interacting molecule 2; 神经元突触膜胞外分泌调节蛋白2; 调节突触膜胞吐蛋白2(RIMS2);


背景信息:
Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis (1-2). Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing (3). Rim1 is expressed near the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3, located on synaptic vesicles (4). Therefore, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5). Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis (3). Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion (6).

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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